ABSTRACT
Objective To explore the compliance rate of patients and its influential factors on topical antifungal treatment of onychomycosis.Methods Dermatology life quality index(DLQI)and self-administered questionnaires were employed in this study.Results The overall compliance rate of the topical antifungal treatment was 23.9%(92/385).The cure rates on onychomycosis in patients with good compliance was 63.04%(58/92),but only 2.05%(6/293)in those noncompliant patients,respectively.Regarding the influencing factors as age,sex,level of awareness,occupation,course of disease,personal income,inconvenience in access to the treatment,keep forgetting in taking the of drug taking was troublesome,together with the quality of life were identified.There were significant differences between those compliant or noncompliant patients.For some factors as adverse effects of drug,number of affected nails,site of the disease,too busy in daily life,lack of related knowledge etc.,no significant differences were found between the compliant or noncompliant patients.Conclusion Our results showed that onychomycosis patients had poor compliance in topical antifungal treatment which significantly influencing the therapeutic effects.Age,sex,level of awareness on the disease,occupation,course of disease,personal income,inconvenience in receiving the treatment,forgetting to take the medicine,lack of patience,lack of confidence,different kinds of misunderstanding about the disease and quality of life etc.might affect the compliance rate of the disease.
ABSTRACT
<p><b>OBJECTIVE</b>To observe the inhibitory effect of mizolastine on substance P(SP)-induced production of leukotriene B(4) (LTB(4)) and interleukin 5 (IL-5) in mouse skin.</p><p><b>METHODS</b>Mice were fed with different doses of mizolastine or other control drugs, 30 min after administration animals were injected intradermally with SP on the back. The treated skin samples were taken and competitive enzyme-link immunoassay (ELISA) method was applied to detect LTB (4) and IL-5 in the skin samples.</p><p><b>RESULT</b>The LTB(4) and IL-5 levels in 10 mg/kg mizolastine group were (1.23 +/-0.29)pg/ml and (34.28 +/-11.00)pg/ml, respectively, which were lower than those in saline control group [(5.52+/-1.88)pg/ml and (179.62 +/-46.25)pg/ml respectively] or loratadine group [(3.89+/-1.27)pg/ml and (127.74 +/-43.27)pg/ml respectively]. No significant difference was found between 10 mg/kg mizolastine group and dexamethasone group (P=0.161 and P=0.508).</p><p><b>CONCLUSION</b>Mizolastine might inhibit the production of LTB(4) and IL-5 induced by substance P in mouse skin, suggesting that anti-inflammatory effect and the blockade of histamine H1 receptors might be involved in its anti-pruritic mechanisms.</p>